In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients


  • Desirèe Padilha Marchetti
  • Bruna Donida
  • Marion Deon
  • Carlos Eduardo Jacques
  • Laura Bannach Jardim
  • Carmen Regla Vargas


X- linked adrenoleukodystrophy, N-acetyl-L-cysteine, glutathione, sulfhydryl


Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated. Results: A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients. Conclusion: These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients.

Keywords: X- linked adrenoleukodystrophy; N-acetyl-L-cysteine; glutathione; sulfhydryl


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Como Citar

Marchetti DP, Donida B, Deon M, Jacques CE, Jardim LB, Vargas CR. In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients. Clin Biomed Res [Internet]. 20º de abril de 2017 [citado 5º de fevereiro de 2023];37(1). Disponível em:



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