A short reflection addressed to the analysts about the relationship between mass spectrometry and sample preparation

Authors

DOI:

https://doi.org/10.22456/2527-2616.142599

Keywords:

Mass spectrometry, Sample preparation, LC-MS

Abstract

Mass spectrometry is one of the most advanced technology applied to qualitative and quantitative analysis. The complexity related to this technique is not the only critical aspect to be considered in the routine of analysis. Actually the quality of analytical results is dependent on previous steps involved to the sample preparation, where well established protocols, conditions, solvents, dilutions, i.e. are crucial to have excellence in the analytical performance. All analysts involved must be qualified and recognize the importance of an integrative view about the sample, from different sources, complex or not, and the protocols to be applied sequentially in order to get prepared for a running through mass spectrometry or hyphenated system (LC-MS). In this work, through a simple and short reflection, the analysts are encouraged to reflect deeply about the importance of these two topics – mass spectrometry and sample preparation – to get excellence during the analytical routine.

Downloads

Download data is not yet available.

References

Ingle RG, Zeng S, Jiang H, Fang W. Current developments of bioanalytical sample preparation techniques in pharmaceuticals. J Pharm Anal. 2022; 12:517-529.

Wieczorek MN, Zhou W, Pawliszyn J. Perspective on sample preparation fundamentals. Adv Sample Prep. 2024; 10:1-20.

Stone J. A practical guide to sample preparation for liquid chromatography-tandem mass spectrometry in clinical research and toxicology. Spectroscopy Europe. 2018; 30(6):15-21.

Vaught JB, Henderson MK. Biological sample collection, processing, storage and information management. IARC Sci Publ. 2011; 163:23-42.

Dinis-oliveira RJ, Vieira DN, Magalhães T. Guidelines for collection of biological samples for clinical and forensic toxicological analysis. Forensic Sci Res. 2016; 1:42-51.

Thomas SN, French D, Jannetto PJ, Rappold BA, Clarke WA. Liquid chromatography-tandem mass spectrometry for clinical diagnostics. Nat Rev Methods Primers. 2022; 96:1-14.

Loss G, Schepdael AV, Cabooter D. Quantitative mass spectrometry methods for pharmaceutical analysis. Philos Trans R Soc A. 2016; 374:1-25.

Downloads

Published

28-12-2024 — Updated on 27-03-2026

Versions

How to Cite

Mendez, A. S. L., & Halquist, M. S. (2026). A short reflection addressed to the analysts about the relationship between mass spectrometry and sample preparation . Drug Analytical Research, 8(2), 3–6. https://doi.org/10.22456/2527-2616.142599 (Original work published December 28, 2024)

Issue

Section

TECHNICAL NOTE