Influence of grape seed oil on sun protection factor in sunscreen formulations: a study using Central Composite Design approach

Paola de Souza Sanches; Samanta Cardozo Mourão; Emeli Moura de Araújo; Natália Farias Santos; Yasmim da Silva Flores; Gabriela Baptista Brito; Carina Quintanilha da Silva; Thamyres Conti dos Santos; Laila Michalski de Oliveira Peixoto; Deborah Quintanilha Falcão

doi:10.22456/2527-2616.125327

Authors

Paola de Souza Sanches Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia - Universidade Federal Fluminense
Samanta Cardozo Mourão Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia; Departamento de Tecnologia Farmacêutica - Universidade Federal Fluminense
Emeli Moura de Araújo Departamento de Tecnologia Farmacêutica - Universidade Federal Fluminense https://orcid.org/0000-0002-8397-5975
Natália Farias Santos Departamento de Tecnologia Farmacêutica - Universidade Federal Fluminense
Yasmim da Silva Flores Departamento de Tecnologia Farmacêutica - Universidade Federal Fluminense
Gabriela Baptista Brito Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia - Universidade Federal Fluminense
Carina Quintanilha da Silva Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia - Universidade Federal Fluminense
Thamyres Conti dos Santos Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia - Universidade Federal Fluminense
Laila Michalski de Oliveira Peixoto Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia - Universidade Federal Fluminense
Deborah Quintanilha Falcão Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia; Departamento de Tecnologia Farmacêutica - Universidade Federal Fluminense

DOI:

https://doi.org/10.22456/2527-2616.125327

Keywords:

Central composite design; grape seed oil, Sun protection factor, Emulsion

Abstract

This study aimed to evaluate the influence of the grape seed oil (GSO) on the sun protection factor (SPF) of sunscreen emulsified formulations containing butyl methoxydibenzoylmethane (avobenzone (AVO)) and octyl methoxycinnamate (OMC) developed by phase inversion temperature (PIT) employing a Central Composite Design. Formulations were prepared by PIT emulsification process. Seventeen emulsions containing different amounts of GSO, AVO and OMC were obtained according to experimental design. In vitro SPF was determined using a spectrophotometric method. As expected, formulations with the highest concentrations of UV filters, AVO and OMC, resulted in the highest SPF values, while the lowest SPF values were obtained by formulations containing concentrations of these filters below the central point. In the tested concentrations, the variable OMC and its combination with GSO showed to influence the SPF linearly as a function of their concentrations in formulations. The combination of GSO with OMC contributed to increase in vitro SPF. The use of natural compounds with antioxidant activity, such as GSO, is a viable strategy to increase the effectiveness of sunscreens to protect the human skin against UV-induced damage.

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