Influence of grape seed oil on sun protection factor in sunscreen formulations: a study using Central Composite Design approach

Authors

  • Paola de Souza Sanches Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Laila Michalski de Oliveira Peixoto Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Thamyres Conti dos Santos aPrograma de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Carina Quintanilha da Silva Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Gabriela Baptista Brito Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Yasmim da Silva Flores Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Natália Farias Santos Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Emeli Moura de Araújo Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil https://orcid.org/0000-0002-8397-5975
  • Samanta Cardozo Mourão Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • Deborah Quintanilha Falcão Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil

DOI:

https://doi.org/10.22456/2527-2616.125327

Keywords:

Central composite design; grape seed oil; Sun protection factor; Emulsion

Abstract

This study aimed to evaluate the influence of the grape seed oil (GSO) on the sun protection factor (SPF) of sunscreen emulsified formulations containing butyl methoxydibenzoylmethane (avobenzone (AVO)) and octyl methoxycinnamate (OMC) developed by phase inversion temperature (PIT) employing a Central Composite Design. Formulations were prepared by PIT emulsification process. Seventeen emulsions containing different amounts of GSO, AVO and OMC were obtained according to experimental design. In vitro SPF was determined using a spectrophotometric method. As expected, formulations with the highest concentrations of UV filters, AVO and OMC, resulted in the highest SPF values, while the lowest SPF values were obtained by formulations containing concentrations of these filters below the central point. In the tested concentrations, the variable OMC and its combination with GSO showed to influence the SPF linearly as a function of their concentrations in formulations. The combination of GSO with OMC contributed to increase in vitro SPF. The use of natural compounds with antioxidant activity, such as GSO, is a viable strategy to increase the effectiveness of sunscreens to protect the human skin against UV-induced damage.

Downloads

Download data is not yet available.

Downloads

Published

2022-07-28

How to Cite

de Souza Sanches, P., Michalski de Oliveira Peixoto, L. ., Conti dos Santos, T. ., Quintanilha da Silva, C. ., Baptista Brito, G. ., da Silva Flores, Y. ., … Quintanilha Falcão, D. . (2022). Influence of grape seed oil on sun protection factor in sunscreen formulations: a study using Central Composite Design approach. Drug Analytical Research, 6(1), 40–45. https://doi.org/10.22456/2527-2616.125327

Issue

Vol. 6 No. 1 (2022)

Section

ORIGINAL ARTICLES

License

Copyright (c) 2022 Drug Analytical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The Copyright holder of manuscripts published is Drug Analytical Research. Authors who publish with this journal are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.


Licensing:

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author.