Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Authors

  • Carolina de Castro Guizelini Laboratório de Anatomia Patológica (LAP), Faculdade de Medicina Veterinária e Zootecnia, (FAMEZ) Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Rayane Chitolina Pupin Laboratório de Anatomia Patológica (LAP), Faculdade de Medicina Veterinária e Zootecnia, (FAMEZ) Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Claudio Severo Lombardo de Barros Laboratório de Anatomia Patológica (LAP), Faculdade de Medicina Veterinária e Zootecnia, (FAMEZ) Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Saulo Petinatti Pavarini Laboratório de Anatomia Patológica (LAP), Faculdade de Medicina Veterinária e Zootecnia, (FAMEZ) Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
  • Danilo Carloto Gomes Laboratório de Anatomia Patológica (LAP), Faculdade de Medicina Veterinária e Zootecnia, (FAMEZ) Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.

DOI:

https://doi.org/10.22456/1679-9216.93926

Abstract

Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but a single case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphoma involving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.

Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseter region, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumor growth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friable areas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head, caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroying the frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to those in the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arranged in a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplastic cells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and the prominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal structure of the tracheobronchial, mediastinal, and internal iliac lymph nodes. In the immunohistochemical examination, labeling was diffuse and moderate in the cytoplasm of neoplastic cells when a CD3 antibody was used, and negative when antibodies to CD79α, cytokeratin, and vimentin were used. Due to its characteristic markings in the immunohistochemistry panel, the neoplasm was classified as an unspecified peripheral T-cell lymphoma.

Discussion: The diagnosis of lymphoma was based on clinical signs and gross and histopathological findings, and was confirmed by immunohistochemistry. Lymphomas in cattle are common in several organs as part of enzootic bovine leukosis, a virus-induced type of B-cell lymphoma. However, lymphomas are rare in the oral cavity. The clinical presentation observed in this case points to the upper alimentary tract as the primary site of the neoplasm once clinical respiratory signs were not observed in the cow. The neoplasm cells described here presented a T-cell profile in immunohistochemistry panel, suggesting that the tumor should be included in the sporadic form of bovine leukosis since B-cells are the cellular population in cases of enzootic bovine leukosis. However, since the diagnosis of enzootic leukosis was not definitively excluded in this case, the cause of the neoplasia cannot be conclusively determined. It is concluded that, although rare, lymphomas may indeed occur in the bovine oral cavity and should be included in the differentials list for tumoral growth in the lateral region of the bovine face.

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References

Berlato D., Schrempp D., Van Den Steen N. & Murphy S. 2011. Radiotherapy in the management of localized mucocutaneous oral lymphoma in dogs: 14 cases. Veterinary and Comparative Oncology. 10(1): 16-23.

Braun U., Brammertz C., Maischberger E., Bass D.A., Klausmann S. & Sydler T. 2015. T-cell lymphoma in the nasal cavity of a Brown Swiss heifer. Acta Veterinaria Scandinavica. 57(8): 1-5.

Boabaid F.M. 2011. Achados clínicos e patológicos da leucose bovina enzoótica. 72f. Porto Alegre, RS. Dissertação (Mestrado em Ciências Veterinárias) - Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul.

Brito M.F., França T.N., Jabour F.F., Seixas J.N., Andrade G.B., Oliveira L.I. & Peixoto P.V. 2009. Metastasizing oral melanoma in a cow. Ciência Rural. 39(4): 1248-1252.

Carvalho F.K.L., Dantas A.F.M., Riet-Correa F., Andrade R.L.F.S., Nóbrega Neto P.I., Miranda Neto E.G., Simões S.V.D. & Azevedo S.S. 2014. Estudo retrospectivo das neoplasias em ruminantes e equídeos no semiárido do Nordeste Brasileiro. Pesquisa Veterinária Brasileira. 34(3): 211-216.

Crocker C.B. & Rings M. 1998. Lymphosarcoma of the frontal sinus and nasal passage in a cow. Journal of the American Veterinary Medical Association. 213(10): 1472-1474.

Fighera R.A. & Barros C.S.L. 2004. Linfossarcoma intracerebral em bovino. Ciência Rural. 34(3): 943-945.

Grunberg W. & Eisenberg S.W.F. 2013. Atypical form of sporadic bovine leukosis (SBL) in the Netherlands. Veterinary Record. 173(16): 398.

Lardé H., Nichols S., Babkine M. & Chénier S. 2014. Laryngeal obstruction caused by lymphoma in an adult dairy cow. The Canadian Veterinary Journal. 55(2): 163-140.

Lucena R.B., Rissi D.R., Kommers G.D., Pierezan F., Oliveira-Filho J.C., Macêdo J.T.S.A., Flores M.M. & Barros C.S.L. 2011. A retrospective study of 586 tumours in Brazilian cattle. Journal of Comparative Pathology. 145(1): 20-24.

Munday J.S., Löhr C.V. & Kiupel M. 2017. Tumors of the alimentary tract. In: Meuten D.J. (Ed). Tumors in Domestic Animals. 5th edn. Ames: John Wiley & Sons, pp.499-601.

Nishimori A., Konnai S., Okagawa T., Maekawa N., Goto S., Ikebuchi R., Nakahara A., Chiba Y. Ikeda M., Murata S. & Ohashi K. 2017. Identification of an atypical enzootic bovine leukosis in Japan by using a novel classification of bovine leukemia based on immunophenotypic analysis. Clinical and Vaccine Immunology. 24(9): 1-14.

Panziera W., Bianchi R.M., Galiza G.J.N., Pereira P.R., Mazaro R.D., Barros C.S.L., Kommers G.D., Irigoyen L.F. & Fighera R.A. 2014. Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma em bovinos: 128 casos (1965-2013). Pesquisa Veterinária Brasileira. 34(9): 856-864.

Prins D.G.J., Wittek T. & Barrett D.C. 2012. Maxillary osteosarcoma in a beef suckler cow. Irish Veterinary Journal. 65(15): 1-4.

Ramos A.T., Souza A.B., Norte D.M., Ferreira J.L.M. & Fernandes C.G. 2008. Tumores em animais de produção: aspectos comparativos. Ciência Rural. 38(1): 148-154.

Reis M.O., Slaviero M., Lorenzett M.P., Cruz R.A.S., Guimarães L.L.B., Pavarini S.P., Driemeier D. & Sonne L. 2017. Neoplasmas de bovinos diagnosticados no Setor de Patologia Veterinária da UFRGS, Porto Alegre (2005-2014). Pesquisa Veterinária Brasileira. 37(2): 105-109.

Tessele B. & Barros C.S.L. 2016. Tumores em bovinos encontrados em abatedouros frigoríficos. Pesquisa Veterinária Brasileira. 36(3): 145-160.

Tsirimonaki E., O’Neil B.W.O., Williams R. & Campo M.S. 2003. Extensive papillomatosis of the bovine upper gastrointestinal tract. Journal of Comparative Pathology. 129(2-3): 93-99.

Tsuka T., Morita T., Tanaka H., Kono S., Murahata Y., Azuma K., Osaki T., Ito N., Okamoto Y. & Imagawa T. 2016. Nasal tissue-derived hamartoma in the maxillary gingiva of a calf. Veterinary Research. 12(19): 1-4.

Valli V.E., Bienzle D. & Meuten D.J. 2017. Tumors of the hemolymphatic system. In: Meuten D.J. (Ed). Tumors in Domestic Animals. 5th edn. Ames: John Wiley & Sons, pp.203-321.

Published

2019-01-01

How to Cite

Guizelini, C. de C., Pupin, R. C., Lombardo de Barros, C. S., Pavarini, S. P., & Gomes, D. C. (2019). Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow. Acta Scientiae Veterinariae, 47. https://doi.org/10.22456/1679-9216.93926

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