Corneal Ulcer in a Southern Brown Howler Monkey (Alouatta guariba clamitans) - Treatment with Heterologous Serum
DOI:
https://doi.org/10.22456/1679-9216.127464Abstract
Background: In the routine care of non-human primates, ocular trauma is frequent, however, unlike the small animal clinic, the prevalence of corneal ulcers is not documented. Among the numerous therapeutic options available in dogs, blood serum is being increasingly used as an adjuvant treatment in these conditions, due to its tear-like properties. Based on this, the present study aims to describe a case of corneal ulcer in a southern brown howler monkey (Alouatta guariba clamitans) attacked by a porcupine, and the use of heterologous serum obtained from an equine as an adjuvant treatment.
Case: A southern brown howler monkey (Alouatta guariba clamitans), which had been attacked by porcupine quills, was treated at a University Veterinary Hospital. During the clinical examination, the presence of blepharospasm and secretion in the right eye was noticed. The ophthalmological examination, through the fluorescein test, detected the presence of an extensive superficial corneal ulcer in the right eye. After removing the spines, the corneal ulcer was treated with tobramycin-based eye drops, 1% atropine sulfate eye drops, and serum from equine blood in the form of eye drops, as an adjuvant therapy. After 5 days of treatment, the fluorescein test was repeated, which was negative in both eyes due to complete healing of the lesion, and thus the treatment was concluded.
Discussion: The scarcity of scientific literature on wild animals is one of the factors responsible for the difficulty in advancing clinical and surgical procedures in non-human primates. Corneal ulcers are characterized by the loss of corneal epithelium with exposure of the stroma. The main clinical treatments adopted include antimicrobial therapy, analgesics, lubricating agents, and antiprotease drugs. Widely used as an adjuvant therapy in corneal ulcers in small animals, blood serum presents some advantages, as it is rich in growth factors, vitamins, immunoglobulins, and anti-collagenolytic substances, in addition to being obtained for a low cost. Considering the aforementioned, in the case reported, it was decided to use blood serum obtained from an equine as an adjuvant treatment of the corneal ulcer in a southern brown howler monkey. Complete healing of the corneal ulcer was confirmed in just five days, contributing to the well-being of this animal and contributing to the evolution of ophthalmology in this species that is still poorly studied.
Keywords: corneal ulcer, southern brown howler monkey, heterologous serum.
Título: Úlcera de córnea em bugio-ruivo (Alouatta guariba clamitans) - tratamento com soro heterólogo.
Descritores: úlcera de córnea, bugio-ruivo, soro heterólogo.
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Bambirra A.L., Oriá A.P., Bahia R., Dórea Neto F.A. & Pinna M.H. 2011. Viabilidade microbiológica do soro sanguíneo autólogo como coadjuvante no tratamento de úlceras de córnea em cães (Canis familiaris, LINNAEUS, 1758). Publicações em Medicina Veterinária e Zootecnia. 5(40): 1-10. DOI:10.22256/pubvet.v5n40.1261. DOI: https://doi.org/10.22256/pubvet.v5n40.1261
Betech H.M., Baca L.O., Velasco R., Levine A., Rodríguez R.A. & Rosales M.M.L. 2007. Hallazgos histopatológicos de la neovascularización corneal en correlacion con la fluorangiografía corneal. Revista Mexicana de Oftalmología. 81(3): 164-170. DOI: 0.1016/j.mexoft.2007.06.002.
Bicca-Marques J.C., Alves S.L. & Ingberman B. 2018. Alouatta guariba clamitans. Cabrera, 1940. In: Instituto Chico Mendes de Conservação da Biodiversidade (Org). Livro Vermelho da Fauna Brasileira Ameaçada de Extinção. Volume II - Mamíferos. Brasília: ICMBio. 2018: 155-161.
Clode A. & Scott E.M. 2021. Clinical pharmacology and therapeutics part 2: antibacterial agents, antifungal agents and antiviral agents. In: Gelatt K.N. (Ed). Veterinary Ophthalmology. 6th edn. Ames: Blackwell Publishing, pp.385-416.
Detwiler S.R. 1939. Comparative studies upon the eyes of nocturnal lemuroids, monkeys, and man. The Anatomical Record. 74: 129-145. DOI: 10.1002/ar.1090740202. DOI: https://doi.org/10.1002/ar.1090740202
Galera P.D., Ávila M.O., Ribeiro C.R. & Santos F.V. 2002. Estudo da microbiota da conjuntiva ocular de macacos-prego (Cebus apela – LINNAEUS, 1758) e macacos bugio (Alouatta caraya – HUMBOLDT, 1812), provenientes do reservatório de Manso, MT, Brasil. Arquivo do Instituto Biológico. 69(2): 33-36. DOI: https://doi.org/10.5216/cab.v14I4.19210. DOI: https://doi.org/10.1590/1808-1657v69n2p0332002
Gelatt K.N. & Samuelson D.A. 1982. Recurrent corneal erosions and epithelial dystrophy in the boxer dog. Journal American Animal Hospital Association. 19: 453-460. DOI: https://doi.org/10.5326/0410158. DOI: https://doi.org/10.5326/0410158
Goto E., Shimura S. & Shimazaki J. 2001. Treatment of superior limbic keratoconjutiviyes by application of autologous serum. The Journal of Cornea and External Disease. 20: 807-810. DOI: 10.1097/00003226-200111000-00006. DOI: https://doi.org/10.1097/00003226-200111000-00006
Kirk E.C. & Kay R.F. 2004. The evolution of high visual acuity in the Anthropoidea. In: Ross C.F. & Kay R.F (Eds). Anthropoid Origins: New Visions. New York: Kluwer Academic/Plenum Publishers, pp.539-602. DOI: https://doi.org/10.1007/978-1-4419-8873-7_20
Kirk E.C. 2006. Effects of activity pattern on eye size and orbital aperture size in primates. Journal of Human Evolution. 51: 159-170. DOI: 10.1016/j.jhevol.2006.02.004. DOI: https://doi.org/10.1016/j.jhevol.2006.02.004
Lagnado R., King A.J., Donald F. & Dua H.S. 2004. A protocol for low contamination risck of autologous serum drops in the manegment of ocular surface disorders. British Journal of Ophtalmology. 88: 464-465. DOI: 10.1136/bjo.2003.025528. DOI: https://doi.org/10.1136/bjo.2003.025528
Lange R.R. 2012. Anatomia, morfologia e fisiologia ocular de algumas espécies de interesse na medicina de animais selvagens e de laboratório com ênfase em primatas neotropicais. 84f. Curitiba, PR. Tese (Doutorado em Ciências Veterinárias) – Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Paraná.
López-García J.S., García-Lozano I., Rivas L. & Martínez-Garchitorena J. 2007. Aplicaciones del suero autólogo en oftalmologia. Archivos de la Sociedad Española de Oftalmologia. 82(1): 9-20. DOI: 10.4321/S0365-66912007000100004. DOI: https://doi.org/10.4321/S0365-66912007000100004
Mattoon J.S. & Nyland T.G. 2005. Olho. In: Nyland T.G. & Mattoon J.S. (Eds). Ultrassom Diagnóstico em Pequenos Animais. 2.ed. São Paulo: Saunders, pp.315-335.
Meekins J.M., Rankin A.J. & Samuelson D.A. 2022. Ophtalmic Anatomy. In: Gelatt K.N. (Ed). Veterinary Ophthalmology. 6th edn. New York: Wiley-Blackwell, pp.53-61.
Mendes S.L., Rylands A.B., Kierulff M.C.M. & de Oliveira M.M. 2008. Alouatta guariba ssp. clamitans. The IUCN Red List of Threatened Species 2008. Disponível em: http://dx.doi.org/10.2305/IUCN.UK.2008.RLTS.T39916A10284881.en. Acesso em: 7 fevereiro 2022. DOI: https://doi.org/10.2305/IUCN.UK.2008.RLTS.T39916A10284881.en
Pan Q., Angelina A., Zambrano A., Marrone M., Stark W.J., Heflin T., Tang L. & Akpek E.K. 2013. Autologous serum eye drops for dry eye. Cochrane Database of Systematic Reviews. 2(2): CD009327. DOI: 10.1002/14651858.CD009327.pub3. DOI: https://doi.org/10.1002/14651858.CD009327.pub2
Partal A. & Scott E. 2011. Low‐cost protocol for the production of autologous serum eye drops by blood collection and processing centres for the treatment of ocular surface diseases. Transfusion Medicine. 21: 271-277. DOI: 10.1111/j.1365-3148.2011.01072.x. DOI: https://doi.org/10.1111/j.1365-3148.2011.01072.x
Pepose J. & Ubels J. 1992. The cornea. In: Hart W. (Ed). Adler’s Physiology of the Eye. Hart W. (Ed.). St. Louis: Mosby Year Book, pp.29-70.
Ranzani J.J.T., Cremonini D.N., Brandão C.V.S., Siqueira A.K. & Chiurciu J.L.V. 2006. Controle microbiológico do soro equino para o tratamento de lesões corneanas. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 58(2): 100-113. DOI: https://doi.org/10.5935/0004-2749.2006000.1.
Ross C.F. & Kirk E.C. 2007. Evolution of eye size and shape in primates. Journal of Human Evolution. 52(3): 294-313. DOI: 10.1016/j.jhevol.2006.09.006. DOI: https://doi.org/10.1016/j.jhevol.2006.09.006
Ross C.F. 2000. Into the light: the origin of Anthropoidea. Annual. Review Anthropology. 29: 147-194. DOI: 10.1146/annurev.anthro.29.1.147. DOI: https://doi.org/10.1146/annurev.anthro.29.1.147
Santo M.R.M. 2012. Estudo da microbiota conjuntival bacteriana de primatas não humanos (Cebus apella e Aotus azarai infulatus) mantidos em cativeiro. 53f. Belém, PA. Dissertação (Mestrado em Saúde e Produção Animal) – Curso de mestrado em Saúde e Produção na Amazônia, Universidade Federal Rural da Amazônia.
Schultz A.H. 1940. The size of the orbit and of the eye in primates. American Journal of Physical Anthropology. 26: 389-408. DOI: 10.1002/ajpa.1330260138. DOI: https://doi.org/10.1002/ajpa.1330260138
Tsubota K., Goto E., Shimmura S. & Shimazakie J. 1999. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 106(10): 1984-1989. DOI: 10.1016/S0161-6420(99)90412-8. DOI: https://doi.org/10.1016/S0161-6420(99)90412-8
Whitley R.D. & Hamor R.E. 2021. Diseases and Surgery of the Canine Cornea and Sclera. In: Gellat K.N. (Ed). Veterinary Ophthalmology. 6th edn. New York: Wiley-Blackwell, pp.1150-1172.
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