TY - JOUR AU - Dutra, Bibiana Kaiser AU - Fernandes, Felipe Amorim AU - Cunha, Gilson Luis da AU - Oliveira, Guendalina Turcato PY - 2009/12/31 Y2 - 2024/03/28 TI - Effects of trans-resveratrol and dimethyl sulfoxide on intermediate metabolism and lipoperoxidation in Drosophila melanogaster JF - Revista Brasileira de Biociências JA - R.bras.Bioci. VL - 7 IS - 4 SE - Artigos DO - UR - https://seer.ufrgs.br/index.php/rbrasbioci/article/view/114895 SP - AB - <p class="MsoNormal" style="margin: 0in 0in 0pt; line-height: 200%; text-align: justify;"><span style="font-size: small;"><span style="font-family: ">Many plants contain the phytoalexin trans-resveratrol, red grapes and peanuts being rich in this antioxidant which is thought to be responsible for the protection which wine have been reported to provide against diseases; many authors considering this antioxidant also to have the ability to retard aging. We investigated the effects of trans-resveratrol on the energetic metabolism in <em style="mso-bidi-font-style: normal;">D. melanogaster </em>during<em style="mso-bidi-font-style: normal;"> </em>the adult life. Adult male and female of the <em style="mso-bidi-font-style: normal;">D. melanogaster </em>were divides into 3 groups: treatment group received 1</span><span style="font-family: Symbol;">m</span><span style="font-family: ">M of trans-resveratrol dissolved in 3% of dimethyl sulfoxide (DMSO), whereas the control group received only DMSO or water. For the analyses of energy metabolism (lipids, triglycerides, cholesterol, glycogen and proteins) and lipoperoxidation the flies were treated during 21 days. All these experiments were repeated five times in five different cohorts.<strong style="mso-bidi-font-weight: normal;"> </strong>Results for the metabolism in control group and treated groups with trans-resveratrol or DMSO showed that both sexes flies showed selective responses to the different treatments. Both sexes of flies treated w<span style="color: #000000;">ith trans-resveratrol or DMSO showed different values for </span>cholesterol, glycogen and total protein as compared to control flies. These results indicate that bo<span style="color: #000000;">th treatments can modulate energy metabolism and lipoperoxidation in this strain of </span><em style="mso-bidi-font-style: normal;">D. melanogaster</em> in both sexes. </span></span></p> ER -