TY - JOUR AU - Polita, Sandra Lermen AU - Massuda, Raffael AU - Panizzutti, Bruna Schilling AU - Gama, Clarissa Severino AU - Duarte, Juliana Avila PY - 2021/10/05 Y2 - 2024/03/29 TI - Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia JF - Clinical and Biomedical Research JA - Clin Biomed Res VL - 41 IS - 3 SE - Artigos Originais DO - UR - https://seer.ufrgs.br/index.php/hcpa/article/view/106797 SP - AB - <p>Introduction: It is well established that cortical volume are decreased in patients<br />with schizophrenia. One possible explanation is that the increased pro-inflammatory<br />status in schizophrenia is related to volumetric decrease of gray matter. The aim of<br />this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with<br />schizophrenia and controls.<br />Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6<br />(IL-6) was correlated with cortical volume in patients with schizophrenia and controls.<br />Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370)<br />in patients, but not in controls (p = 0.235).<br />Discussion: Our results are in line with previous studies suggesting that chronic<br />inflammatory activation in patients with schizophrenia could be one plausible mechanism<br />that could contribute for the cortical volumetric decrease often seen in this population.<br />However, this cross-sectional study with a small number of patients does not allow<br />us to establish causal relations.</p> ER -