TY - JOUR AU - Pequeno, Nebson Fernandes AU - Soto-Blanco, Benito PY - 2018/06/27 Y2 - 2024/03/28 TI - Toxicidade in vitro de plantas tóxicas: avaliação do teste de ação hemolítica JF - Acta Scientiae Veterinariae JA - Acta Scientiae Vet. VL - 34 IS - 1 SE - DO - 10.22456/1679-9216.15066 UR - https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/15066 SP - 45-48 AB - <span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><font face="Times-Roman" size="2" color="#231f20"><font face="Times-Roman" size="2" color="#231f20"><font face="Times-Roman" size="2" color="#231f20"><p align="left">As plantas tóxicas são importantes causas de patologias em animais de interesse pecuário no Brasil. Para que umaplanta apontada como responsável por intoxicações acidentais venha a ser classificada como espécie tóxica, sua toxicidade deve ser comprovada experimentalmente em animais. No entanto, a sociedade atual vem clamando por redução na utilização de animais em pesquisas científicas, fazendo com que testes de toxicidade</p></font></font></font></span><font face="Times-Roman" size="2" color="#231f20"><font face="Times-Roman" size="2" color="#231f20"><p align="left"> </p></font></font></span><font face="Times-Roman" size="2" color="#231f20"><p align="left"> </p></font></span><p align="left"><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">in vitro </span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">sejam cada vez mais empregados. Como falta validação para o uso destes testes para avaliação de plantas tóxicas, seu uso prático se torna inviável. Assim, o objetivo do presente trabalho foi avaliar a eficácia do teste de ação hemolítica </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">in vitro </span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">para avaliação preliminar da toxicidade de plantas, usando espécies com toxicidade conhecida. As espécies de plantas usadas foram </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Crotalaria retusa</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Ipomoea asarifolia</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Ipomoea fistulosa</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Datura stramonium</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Nerium oleander</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Ricinus communis</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Lantana camara</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Dieffenbachia picta </span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">e </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Alocacia </span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">sp. e </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">Calotropis procera</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">. Todas estas amostras foram submetidas à avaliação da ação hemolítica </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">in vitro</span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">, utilizando-se uma suspensão de eritrócitos de eqüino. Nenhuma das plantas utilizadas apresentou este efeito hemolítica. Assim, é possível afirmar que a utilização do teste de hemólise </span></span></span><em><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;"><span style="font-family: Times-Italic; color: #231f20; font-size: x-small;">in vitro </span></span></span></em><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;"><span style="font-family: Times-Roman; color: #231f20; font-size: x-small;">é ineficaz para a avaliação preliminar, como triagem, de plantas tóxicas. Deste modo, o uso de animais de laboratório atualmente permanece sendo a forma mais eficaz de identificação de novas espécies de plantas tóxicas.</span></span></span></p> ER -