Iliac Lymphadenectomy following Intrauterine Mapping in a Female Dog with Breast Neoplasm

Authors

  • João Pedro Scussel Feranti Surgery and Veterinary Clinic Department, University of the Campanha Region (URCAMP), Alegrete, RS, Brazil. Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Gabriela Pesamosca Coradini Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Marcella Teixeira Linhares Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Hellen Fialho Hartmann Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Rammy Vargas Campos Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Marília Teresa de oliveira Veterinary Clinics Department, Federal University of Pampa (UNIPAMPA), Uruguaiana, RS.
  • Rafael Oliveira Chaves Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS.
  • Alvaro José Chávez Silva Graduate Program of Veterinary Medicine, Federal University of Santa Maria (UFSM), Santa Maria, RS. Animal Welfare Department, National Autonomous University of Nicaragua (UNAN), Leon, Nicaragua.
  • Maurício Veloso Brun PPPGMV, UFSM, Santa Maria.

DOI:

https://doi.org/10.22456/1679-9216.86421

Abstract

Background: The lymphatic system plays an important role in the local control of neoplasms as well as in the transportation of tumor cells, which represents the most common pathway of metastasis. From the tumorigenesis, there is a remarkable enlargement of the tumor drainage network towards the regional and target lymph nodes. Since the mammary lymphatic system of animals with neoplasms as well as the demarcation of the pelvic and abdominal caudal chain are poorly studied, the aim of the present study is to report a case of iliac lymphadenectomy after intrauterine lymphatic dyeing in a dog with breast neoplasm, which allowed the identification of metastasis in the medial iliac lymph node.
Case: A 7-year-old, 13.4 kg, non neutered, mixed breed, female dog was diagnosed with ulcerative neoplasm in the left caudal abdominal breast, which presented evolution of approximately 90 days, presenting ulceration for 10 days, according to the tutor. After a clinical evaluation, thoracic radiography and abdominal ultrasonography were requested, which
did not present metastasis suggestive images. Therefore, left unilateral total mastectomy was indicated. Retro-umbilical celiotomy was performed for the administration of 0.5 mL of 1% intrauterine methylene blue (body of the uterus), which allowed lymphatic mapping and medial iliac lymphadenectomy. Subsequently, ovariohysterectomy was performed and
after celiorrhaphy, axillary lymphadenectomy was performed, followed by left unilateral mastectomy and concomitant removal of the superficial inguinal lymph node. The patient had a prompt recovery and was discharged from hospital in six hours postoperatively. The excised material was referred for histopathological examination, which revealed the presence of metastasis of simple tubulopapillary carcinoma of the mammary gland in the left medial and superficial inguinal lymph nodes, while the axillary lymph node had no metastases. At the end of 10 days, the patient was clinically stable, with good healing of the surgical wound. After a 120-day postoperative period, the patient had a good clinical status, with no respiratory alterations, and there was no evidence of metastasis on the chest X-ray as well as abdominal ultrasound.
Discussion: Considering the great occurrence of breast neoplasms, it is important to develop studies on new approaches in the therapeutic management of this condition and sharing of reports as described. The objective of the lymphadenectomy was to evaluate the possible involvement of regional lymph nodes, since, according to the condition of the lymph nodes in the histopathological examination, it appears as an important prognostic factor, seeing that the survival time is less than
two years for 85.7% in dogs with regional lymph node metastases. In animals, there are no studies based on the therapeutic alternative of lymphadenectomy, which is believed to be palliative in the reported patient, due to the fact that it is a tubulopapillary carcinoma with different foci of lymph node metastases. Otherwise, lymphadenectomy enabled a better definition of the prognosis and proved to be an important tool for staging. The use of methylene blue was chosen because it was reportedly used in dogs, with excellent results in sentinel lymph nodes mapping, and due to its ease of obtaining and low cost of application. It is concluded that in canines with breast neoplasms, it is important to perform lymphatic mapping to identify possible metastases in cellular tissues and to delimit regional lymph vessels and lymph nodes, thus facilitating the surgical removal of these structures with safety margins. In addition, it is important to perform lymphadenectomy even to lymph nodes that are not infarcted or present macroscopic changes, given that in this case, it already existed metastasis, even in a lymph node of 4 mm.
Keywords: metastasis, sentinel lymph node, lymphatic mapping, mastectomy, canine.

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References

Beserra H.E. 2016. O. Linfonodo sentinela. In: Daleck C.R. & de Dardi A.B. (Eds). Oncologia em cães e gatos. São Paulo: Roca, pp.128-132.

Branco A.W. & Kondo W. 2007. Linfadenectomia por vídeo-laparoscopia no câncer de próstata. Revista brasileira de videocirurgia. 5(3): 121-127.

Brenet O., Lalourcey L. & Queinnec M. 2013. Hypersensitivity reactions to patent blue v in breast cancer surgery: a prospective multicentre study. Acta Anesthesiology Scandinava. 57(1): 106-117.

Castelo D., Figueiredo A. Parada B., Nunes P. & Mota A. 2010. O papel da linfadenectomia pélvica nos doentes submetidos a prostatectomia radical. Acta urológica. (4): 17-27.

Cowell R.L., Dorsey K.E. & Meinkoth J.H. 2003. Lymph node cytology. Veterinary Clinical North American Small Animal Practice. 33(1): 47-67.

de Nardi A.B., Ferreira T.M.M.R. & Assunção K.A. 2016. Neoplasias mamárias. In: Daleck C.R. & de Nardi A.B. (Eds). Oncologia em cães e gatos. São Paulo: Roca, pp.498-516.

Jeudy G. Louvier N., Rapennes T., Goujon E., Fraisse J., Dalac-Rat S. & Collet E. 2008. Immediate patent blueinduced hypersensitivity during sentinel node detection: the value of cutaneous tests. Annales de Dermatologie et de Vénéréologie. 135(6): 461-465.

Justino R.C., Cardoso G.S., Trautwein L.G.C., Dessunti G.T., Oliveira D.V., Bernardes R. & Martins M.I.M. 2014. Uterine lymphangiography: comparison of two methods for locating the medial iliac lymph node. Pesquisa Veterinária Brasileira. 34(11): 1121-1126.

Karayannopoulou M., Kaldrymidou E., Constantinidis T.C. & Dessiris A. 2005. Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method. Journal of Comparative Pathology. 133(4): 246-252.

Maranhão M.V.M., Nóbrega D.K.A, Anunciação C.E.C., Maia B.A.B. & Mariano P.V.D. 2016. Allergic reaction to patent blue dye in breast surgery – case report. Brazilian Journal of Anesthesiology. 66(4): 433-436.

Miyashiro I., Kishi K., Yano M., Tanaka K., Motoori M., Ohue M., Ohigashi H., Takenaka A., Tomita Y. & Ishikawa O. 2011. Laparoscopic detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence

imaging. Surgical Endoscopy. 25(5): 1672-1676.

Patsikas M.N., Karayannopoulou M., Kaldrymidoy E., Papazoglou L.G., Papadopoulou P.L., Tzegas S.I., Tziris N.E., Kaitzis D.G., Dimitriadis A.S. & Dessiris A.K. 2006. The lymph drainage of the neoplastic mammary glands

in the bitch: a lymphographic study. Anatomia, histologia e embryologia. 35(4): 228-234.

Pereira C.T., Rahal S.C., de Carvalho Balieiro J.C. & Ribeiro A.A. 2003. Lymphatic drainage on healthy and neoplasic mammary glands in female dogs: can it really be altered? Anatomia, histologia, embryologia. 32(5): 282-290.

Pinheiro L.G.P., Moraes M.O., Soares A.H., Lopes A.J.T., Naguére M.A.S.P., Gondim F.A.L., Brandão C.B., Nascimento D.C.H., Soares J.P.H. & Silva J.M.M. 2003. Estudo experimental de linfonodo sentinela na mama da

cadela com azul patente e tecnécio tc99. Acta Cirúrgica Brasileira. 18(6): 545-552.

Pinheiro L.G.P., Oliveira Filho R.S., Vasques P.H.D., Filgueira P.H.O., Aragão D.H.P., Barbosa P.M.E., Beserra H.E.O. & Cavalcante R.V. 2009. Hemosiderin. A new marker for sentinel lymph node identification. Acta Cirúrgica Brasileira. 24(6): 432-436.

Suga K., Karino Y., Fujita T., Okada M., Kawakami Y., Ueda K., Yuan Y. & Matsunaga N. 2007. Cutaneous drainage lymphatic map with interstitial multidetector-row computed tomographic lymphography using iopamidol:

preliminary results. Lymphology. 40(2): 63-73.

Wainstein A.J.A., Barbosa L.C.C.S., Kansaon M., Salomé M. & Drummond-Lage A.P. 2015. Advanced malignant melanoma during pregnancy: technical description of sentinel lymph node biopsy followed by radical lymph node dissection. Revista Brasileira de Saúde Materna Infantil. 15(4): 447-450.

Wells S., Bennett A., Walsh P., Owens S. & Peauroi J. 2006. Clinical usefulness of intradermal fluorescein and patent blue violet dyes for sentinel lymph node identification in dogs. Veterinary and Comparative Oncology. 4(2): 114-122.

Published

2018-01-01

How to Cite

Feranti, J. P. S., Coradini, G. P., Linhares, M. T., Hartmann, H. F., Campos, R. V., de oliveira, M. T., Chaves, R. O., Silva, A. J. C., & Brun, M. V. (2018). Iliac Lymphadenectomy following Intrauterine Mapping in a Female Dog with Breast Neoplasm. Acta Scientiae Veterinariae, 46, 4. https://doi.org/10.22456/1679-9216.86421

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