Sublingual immunotherapy in the treatment of allergic asthma: a systematic review with meta-analysis

Cristian Roncada, Bianca Martininghi Bugança, Karina Soldera, Paulo Márcio Pitrez


Introduction: The guidelines for the management of allergic respiratory diseases oriented towards control from medical treatment combined with measures of environmental hygiene. Immunotherapy is one of several types of treatment, applied in combination with prophylactic drugs and environmental care. The aim of the study is to evaluate the efficacy of sublingual immunotherapy (SLIT) for house dust mites (HDM) in people with allergic asthma.

Methods: The study is based on a systematic review with meta-analysis of randomized clinical trials, associating sublingual immunotherapy with the treatment of allergic patients with HDM.

Results: The searches were applied in PubMed, ScienceDirect and Scielo databases. Initially, 98 articles were recovered, of which only nine were eligible. Of these, eight (88.9%) were conducted in Europe and only one (11.1%) in Asia. Comparing the outcomes expiratory volume in the first minute (FEV1) and sensitivity to allergens (HDM) between SLIT and placebo groups before and after intervention, no differences were observed between the groups.

Conclusions: SLIT is not evidenced significantly by meta-analysis for the treatment of allergic asthma.

Keywords: Mites; asthma; rhinitis; respiratory disease


Mites; asthma; rhinitis; respiratory disease

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ISSN: 2357-9730




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