Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy – CADASIL

Rosane Brondani, Andrea Garcia Almeida, Vicenzo Zarpellon de Araújo, Larissa Bianchin, Suelen Mandelli Mota, Bárbara Reis Krammer, Martina Camerini Marafon, Eduardo de Carvalho Mazzocato, Marino Muxfeldt Bianchin

Abstract


We report here neuroimaging findings of a  41 years-old female with molecular diagnosis of CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). CADASIL, the most common form of hereditary stroke, is characterized by headaches and relapsing strokes. More than 95% of patients present mutations of NOTCH3 gene. MRI, the best neuroimaging modality to investigate CADASIL can show lacunar infarcts and less-well demarcated T2 weighted hyperintensities characteristically located in subcortical white matter. There is no specific treatment for CADASIL. Anti-platelet agents such as aspirin might help to prevent new strokes. Other symptoms, like headache, seizures, or other neuropsychiatric manifestations should be appropriately treated.


Keywords


stroke, headache, migraine, CADASIL

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ISSN: 2357-9730 

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The Clinical & Biomedical Research is licenced under Creative Commons Atribuição 4.0 Internacional.