Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy – CADASIL

Autores

  • Rosane Brondani Division of Neurology, Hospital de Clínicas de Porto Alegre
  • Andrea Garcia Almeida Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Vicenzo Zarpellon de Araújo Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Larissa Bianchin Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Suelen Mandelli Mota Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Bárbara Reis Krammer Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Martina Camerini Marafon Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Eduardo de Carvalho Mazzocato Division of Neurology, Hospital de Clínicas de Porto Alegre.
  • Marino Muxfeldt Bianchin Hospital de Clínicas de Porto Alegre.

Palavras-chave:

stroke, headache, migraine, CADASIL

Resumo

We report here neuroimaging findings of a  41 years-old female with molecular diagnosis of CADASIL (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy). CADASIL, the most common form of hereditary stroke, is characterized by headaches and relapsing strokes. More than 95% of patients present mutations of NOTCH3 gene. MRI, the best neuroimaging modality to investigate CADASIL can show lacunar infarcts and less-well demarcated T2 weighted hyperintensities characteristically located in subcortical white matter. There is no specific treatment for CADASIL. Anti-platelet agents such as aspirin might help to prevent new strokes. Other symptoms, like headache, seizures, or other neuropsychiatric manifestations should be appropriately treated.

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Biografia do Autor

Marino Muxfeldt Bianchin, Hospital de Clínicas de Porto Alegre.

Associated Professor

Department of Internal Medicine

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Publicado

2017-01-17

Como Citar

1.
Brondani R, Almeida AG, de Araújo VZ, Bianchin L, Mota SM, Krammer BR, Marafon MC, Mazzocato E de C, Bianchin MM. Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy – CADASIL. Clin Biomed Res [Internet]. 17º de janeiro de 2017 [citado 3º de outubro de 2022];36(4). Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/66306

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Relatos de Casos: Imagens em Medicina

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