Posssible enhancement of long-term fear conditioning performance by cisplatin administration in rats

Bruno Kilpp Goulart, Algemir Lunardi Brunetto, Gilberto Schwartsmann, Silvia Ramos Hecktheuer, Gustavo Kellermann Reolon, Natasha Maurmann, Rafael Roesler


Background: Neurocognitive deficits associated with chemotherapy represent an increasing concern, and the development of animal models to investigate chemotherapy-induced alterations in memory is warranted

Aims: To examine the effects of systemic injection of cisplatin on formation of fear-motivated memory in rats.

Methods: Male Wistar rats were given an intraperitoneal (i.p.) injection of saline or cisplatin followed by inhibitory avoidance (IA) training. Memory retention was tested 1 and 7 days after training. Control experiments using an open field were carried out to confirm the specificity of the cisplatin-induced alteration in IA performance.

Results: Cisplatin induced a unexpected enhancement of IA performance measured 7 days after drug injection and training. Control experiments suggested that the effect could not be attributed to sensorimotor alterations or toxic effects.

Discussion: The findings are discussed in the light of previous preclinical evidence that cancer chemotherapy can, under some conditions, lead to memory enhancement.


cisplatin; cancer chemotherapy; memory; cognitive function; animal modelsossi

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ISSN: 2357-9730 





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