Diagnosis, risk factors and pathogenesis of preeclampsia

Rafael Bueno Orcy, Renata Pedrini, Pedro Piccinini, Sabrina Schroeder, Sérgio Hofmeister Martins-Costa, José Geraldo Lopes Ramos, Edison Capp, Helena von Eye Corleta


Preeclampsia is an illness of the gestation that involves fetal growth restriction, prematurity and, in more severe cases, death of mother and fetus. It is characterized by maternal hypertension, significant proteinuria (? 0,3g/24 h), edema, vasoconstriction of maternal blood vessels and consequent increase in vascular resistance. Many studies discuss risk factors, pathogenesis and diagnostic criteria of preeclampsia; however, there are large variations in presentation and clinical course of this illness, which make interpretation of fre-quently conflicting results difficult. Diagnostic standardization and research of genetic and molecular bases can bring a better understand-ing of this pathology in a near future. In this paper, we present a review of the literature, stressing the relation between preeclampsia and insulin resistance.


pré-eclâmpsia; diagnóstico; fatores de risco; fisiopatologia; resistência à insulina

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ISSN: 2357-9730 




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