AneliseUsuário do Windows212021-05-03T20:17:00Z2021-07-30T19:08:00Z2021-07-30T19:08:00Z31664949179221113315Title: use times new roman font, 14 points size, bold style, centralized, spacing 1.0, lowercase (DAR title 1 style)Principle Authora, Corresponding author*b and Co-authors, First Middle Last names: use times new roman font, 11 points size, centralized, spacing 1.0 (DAR author style)aDepartment Name, Faculty Name, University Name, City, Country; bDepartment Name, Faculty Name, University Name, City, Country (times new roman font, 10 points size, italic style, centralized)*Corresponding author: add the e-mail address(times new roman font, 10 points size, italic style, centralized) (DAR address style)The abstract should have no more than 250 words (Review and Original Articles). Write using times new roman font, 10 points size, justified.Keywords: authors should indicate 3 to 5 keywords separated by semicolon. Employ controlled vocabulary as indicated at https://decs.bvsalud.org. Use times new roman font, 10 points size, justified, spacing 1.0.Article received at dd/mm/yyyy and accepted at dd/mm/yyyy.https://doi.org/First author et al. Article title in abbreviated format (no more than ninety characters with spaces) PAGE \* MERGEFORMAT 1DRUG ANALYTICAL RESEARCHISSN: 2527-2616 www.seer.ufrgs.br/dar HYPERLINK "http://www.seer.ufrgs.br/dar" Drug Anal. Res., Porto Alegre, v. x, n. x, p. xx-xx, Jan./June or July/Dec. 202xIntroduction (times new roman font, 12 points size, bold style, justified, spacing 1.0) (DAR title 2 style)Original Articles should contain no more than 25 pages and not exceed 6,000 words. For Review Articles, until 9,000 words will be accepted. Manuscripts must be written using Microsoft Word for Windows, Times New Roman font, 10 points size and black color. Space between lines must be 1.0 without spacing before/after the paragraphs. Pages must be consecutively numbered, in the bottom right-hand corner of the page. Page’s margins should be moderate one (2.5 cm upper/lower, 1.9 cm left/right). The space between columns is 0.7 cm. Section titles must be written in bold style, 12 points size and subtitles in italic plus bold styles, 10 points size. Additional subsections must be written only in italic style.The manuscript must be clear and concise. The Introduction section should identify in a clear and brief way, through using relevant references, the nature of the problem under investigation and the previous knowledge about it. Extensive literature review will not be accepted. (times new roman font, 10 points size, justified, spacing 1.0 all the text) (DAR text style).Experimental section (DAR title 2 style)The Experimental section should precede the Results and Discussion one. The Experimental section must describe in a clear and objective way the methodology used. The purity degree of reagents should be cited. Description of well-established procedures is not necessary. Supplementary section can be adopted and positioned before References. The instrumental applied should only be cited if not usual, indicating their brands and models. Every experimental study on humans or animals must be proven to have the prior approval of the appropriate institutional review body. Results and DiscussionSubsection: Nomenclature (times new roman font, 10 points size, bold italic, justified, spacing 1.0) (DAR title 3 style)Unities of weight and measurements, names of plants, animals, and chemicals should be mentioned according to the International Rules available. Concentration expressions should be presented like the following example: mg.mL-1, mg.g-1.Subsection: Figures and Charts (times new roman font, 10 points size, bold italic, justified, spacing 1.0)Illustrations (photographs, charts, drawings, etc.) should be sent in separate files, in JPG format (at a high resolution - at least 300 dpi). They should be numbered consecutively with Arabic numerals, in the order that they are cited in the text and should be clear enough for reproduction and in the same language as the text. If there are figures extracted from other previously published studies, the authors should provide a written permission for their reproduction. This authorization shall accompany the manuscript submitted for publication. The figures must have title and subtitle (if necessary), which should be positions below the figure itself. Second subsection: Local for Figures and Charts (times new roman font, 10 points size, only italic, justified, spacing 1.0) (DAR title 4)The figures should be already inserted in the manuscript text body, but this does not exclude their sending in separate files. Large figures can be presented out of two column layout employing section break. When sending illustrations only in separate files, the figure captions should be listed in the last page of the manuscript./9j/4AAQSkZJRgABAQEA3ADcAAD/2wBDAAIBAQEBAQIBAQECAgICAgQDAgICAgUEBAMEBgUGBgYF
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Figure 1. Chemical structure with its font even when made by the authors (times new roman font, 9 points size, justified) (DAR legend style).Subsection: Tables They should be numbered consecutively, with Arabic numerals, in the order they were cited in the text and headed by a suitable title. Any extra information should be in under position in the table, as a footnote. Like illustrations, the tables should be already inserted in the manuscript text body always employing Microsoft Word for Windows and avoiding vertical lines. Large tables can be presented out of two column layout employing section break. Table 1. (times new roman font, 9 points size, justified; to the title and the table data).DrugTheoretical(μg.mL-1)Experimental1(μg.mL-1)Accuracy2(%)RSD3(%)4849.42102.951.21A6060.29100.497273.15101.6044.11102.781.10B55.03100.5666.09101.471Mean of three replicates, 2Percentage data recoveries, 3RSD (Relative standard deviation).Subsection: Abbreviations Must be explained at first mention. On the rest of the article, it is not necessary to repeat the full name. Name of medications: the generic name should be used. In case of citing appliances/equipment: all item cited should include manufacturer's name, model, city, and country of manufacture. ConclusionsConclusions should summarize the main finding of the work and be written before Acknowledgements.AcknowledgmentsShould include the collaboration of people, groups or institutions that have contributed to the study, but whose contributions do not justify their inclusion as authors; this item should also include the acknowledgments for financial support, technical assistance, etc. This item should come before the References.Conflict of interestIf there is any conflict of interest, it should be declared. In case there is not, place in this section: "The authors declare no conflicts of interest" or "None to declare".Supplementary sectionsSupplementary sections, if necessary, must contain relevant and complementary information, besides those presented in the manuscript.ReferencesShould be numbered consecutively, in the order in which they are mentioned in the text between parentheses, any identified with Arabic numerals (for example: 1-3, 5, 7). No spacing between paragraphs are required (DAR references style). The authors should ensure that the cited references in the text appear in the Reference list with exact dates and author's names correctly spelled. The accuracy of references is the author's responsibility. The recommended style for references is based on the National Information Standards Organization NISO Z39.29-2005 (R2010) Bibliographic References as adapted by the National Library of Medicine. Fuller explanations are in Citing Medicines https://www.nlm.nih.gov/bsd/uniform_requirements.html.Examples of citing references: Journal articles (from one to six authors) Raju CK, Pandey AK, Gururaj S, Ghosh K, Pola A, Goud PSK, et al. Isolation and characterization of novel degradation products of doxofylline using HPLC, FTIR, LCMS and NMR. J Pharm Biomed Anal. 2017; 140:1-10.Articles without the author’s name Cancer in South Africa [editorial]. S Afr Med J. 1994; 84:15.Chapters from a book Gonçalves JE, Storpirtis, S. O Sistema de Classificação Biofarmacêutica: conceitos, determinação da solubilidade e permeabilidade e aplicações na área farmacêutica. In: Vieira NR, Campos DR, editors. Manual de bioequivalência. 2nd ed. São Paulo: Dendrix; 2011. p. 137-70. Série Pesquisa Clínica. Portuguese.Books/E-books in which editors (organizers) are authorsNorman IJ, Redfern SJ, editors. Mental health care for elderly people. New York: Churchill Livingstone; 1996.Gilstrap LC 3rd, Cunningham FG, VanDorsten JP, editors. Operative obstetrics. 2nd ed. New York: McGraw-Hill; 2002. E-book.Organization as authorInternational Conference on Harmonization (ICH) of Technical Requirements for the Registration of Pharmaceutical for Human Use. Validation of analytical procedures: text and methodology Q2(R1). Geneva; 2005. Agência Nacional de Vigilância Sanitária (BR). Resolução RDC n° 166 de 27 de julho de 2017. Dispõe sobre a validação de métodos analíticos e dá outras providências. Brasília, DF: Diário Oficial da União; 2017. Portuguese.Pharmacopeia/ Legal materialUnited States Pharmacopeia. USP 43–NF 38. Rockville: The United States Pharmacopoeial Convention; 2020.Health Canada. Drug Product Database [Internet]. Canada [updated 2021 Mar 15; cited 2021 Jul 09] Available from: https://health-products.canada.ca/dpd-bdpp/index-eng.jsp. PatentPagedas AC, inventor; Ancel Surgical R&D Inc., assignee. Flexible endoscopic grasping and cutting device and positioning tool assembly. United States patent US 20020103498. 2002 Aug 1.Electronic Journal Articles Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs. 2002 Jun [cited 2002 Aug 12];102(6):[about 1 p.]. Available from: https://ovidsp.tx.ovid.com/ Subscription required.ThesesKaplan SJ. Post-hospital home health care: the elderly’s access and utilization [dissertation]. St. Louis (MO): Washington University; 1995. Papers presented at conferencesBengtsson S, Solheim BG. Enforcement of data protection, privacy and security in medical informatics. In: Lun KC, Degoulet P, Piemme TE, Rienhoff O, editors. MEDINFO 92. Proceedings of the 7th World Congress on Medical Informatics; 1992 Sep 6-10; Geneva, Switzerland. Amsterdam: North-Holland; 1992. p. 1561-5.Note:Authors can adopt the journal's writing styles (resource of Microsoft Word), which format the text in an easier way. The styles are presented below in approximate order of appearance in the manuscript: DAR title 1DAR authorDAR addressDAR title 2DAR textDAR legendDAR title 3DAR title 4DAR referencesDrug Anal. Res., Porto Alegre, v. x, n. x, p. xx-xx, Jan./June or July/Dec. 202x PAGE \* MERGEFORMAT 2If necessary, large figures and large tables can be insert at the end of the text, employing one column layout, like this example:Table 2. (times new roman font, 9 points size, justified; to the title and the table data).Skin layersDrugLevelDay 1Day 2RSD (%) inter-dayAveragerecovery (%)RSD (%)intra-dayAveragerecovery (%)RSD (%)intra-dayLow93.4712.4896.100.867.97EpidermisIntermediate95.846.7492.997.086.40High98.991.4393.995.694.61Low104.445.34101.453.154.50DermisIntermediate89.708.4789.901.965.57High96.744.1698.330.825.03