Morphological changes in epithelium of the tongue of mice exposed to 40º GL alcohol solution

J. C. Sanfelice, D. M. P. Padilha, M. Sant'Ana Filho


Alcohol, itself was never pointed as a carcinogen. Literature refers to alcohol as an ind uctor or as element that would act in synergy with th e tobacco in oral cancer development. ln order to evaluate the alcohol role in oral can cer carcinogenesis, an experiment with 60 mice divided in three groups - Control, Continuous Alcohol and Topic Application Group - during one year period was accomplished. Animals of ali groups were fed with stanqard rat pellets. The rats from Alcohol Contínuos Group have received alcohol 40°GL as liquid diet. Topic alcohol application drinking group received water and an application of alcohol 40°GL twice a week simulatin g eventual consumption. Samples from tongue dorsu m were obtained a t the begin ning of the experiment and after every six months. The samples were processed for histological analysis. It was evaluated and changes were measured in the epitheliu m (epithelium thickness, keratin layer thickness, relationship between epithelium basal layer and superficial layer and relationship of n ucleus­ cytoplasm area (basal and intermedia t e layer). Throughout statistical analysis significant changes were found in almost ali evaluated items. It was concluded that alcohol could be pointed out as an oral m ucosa morphology-changing agent when consum ed contin uously or topically applied.


Alcohol; Tongue morph ology; Oral mucosa; Mount alcohol effects


Licença Creative Commons

e-ISSN 2177-0018 / ISSN 0566-1854.

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