Psycho-emotional stress - A cause of coronary artery disease

Davidraj Chellappan, Jipnomon Joseph, Mohamed Shabi, Gayathri Krishnamoorthy, Dhevi Ravindhran, Subashini Uthrapathy, Victor Rajamanickam, Govindha Dubey

Abstract


Psycho-emotional stress is one of the risk factors for metabolic syndrome and related diseases. Hence, this study has designed to the effect of psycho-emotional stress in the form of immobilization stress in rabbits. In this study, we used 12 male New Zealand White rabbits (2.5 -3 kg body weight), Six animals for hanging fixation and another six as control. Blood samples were taken before hanging (0 minute) and at 60, 120 minutes. Serum was separated and used for the estimation of various biochemical parameters. Hanging fixation appears to produce significant increase in malondialdehyde and lipid profile levels. The non-enzymatic antioxidants like reduced glutathione, vitamin E and ceruloplasmin were found to be decrease and the level of enzymatic antioxidant like glutathione peroxidase was increased significantly. The results reveal that the hanging fixation may develop coronary artery disease. This is the area, which should be evaluated further by carrying out chronic studies in hung stress and by histopathological studies.


Keywords


Lipid profile; Oxidative stress; Hung stress; Rabbit; Lipid peroxidation



DOI: https://doi.org/10.22456/1679-9216.17275

Copyright (c) 2018 Davidraj Chellappan, Jipnomon Joseph, Mohamed Shabi, Gayathri Krishnamoorthy, Dhevi Ravindhran, Subashini Uthrapathy, Victor Rajamanickam, Govindha Dubey

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This work is licensed under a Creative Commons Attribution 4.0 International License.