Juvenile-Onset Ischemic Dermatopathy in a Dog


  • Gabriela Cousandier Clínica Saúde Animal, Bento Gonçalves, RS, Brazil.
  • Ariane Damiani Scholten Clínica Saúde Animal, Bento Gonçalves, RS, Brazil.
  • Gisele Scotton Clínica Saúde Animal, Bento Gonçalves, RS, Brazil.
  • Carine Stefanello Clínica Saúde Animal, Bento Gonçalves, RS, Brazil.




Background: Juvenile-onset ischemic dermatopathy is a rare dermatosis in dogs. Reports on this condition are scarce in the literature, and its pathogenesis is poorly understood. This disease consists of a set of alterations that exhibit similar clinical and histological characteristics, and which are associated with cutaneous vasculopathic processes. Consequently, this case report describes the clinical case of a dog diagnosed with juvenile-onset ischemic dermatopathy. 

Case: A 9-month-old female mongrel dog exhibited significant tegumentary alterations, while other contact animals (siblings and mother) did not. The patient history did not contain a complete record of vaccines, and included previous therapeutic failures. A general skin examination revealed the presence of erythematous lesions containing crusts and erosions associated with extended areas with alopecia, especially in the ears, nose, and tail. Therefore, skin cytology and a parasitological examination of the skin and cerumen were performed. These tests revealed the presence of neutrophilic inflammatory process, bacterial inflammation, and various yeast-like structures compatible with Malassezia sp. The parasitological examination of the cerumen revealed the presence of numerous mites of the Otodectes cynotis species.Consequently, the dog received a treatment that included amoxicillin with potassium clavulanate, itraconazole, therapeutic baths with a shampoo containing chlorhexidine and miconazole, and an antiparasitic medication containing sarolaner, which was administered once every 35 days. Thirty days later, the patient returned with a significant improvement of the lesions, except those in the ears and tail; consequently, material from these two body areas was submitted to histopathological examination, and additional tests were performed to allow differential diagnosis. The histopathological report indicated the existence of interface dermatitis (cytotoxic), and suggested the clinical hypothesis of chronic juvenile ischemic dermatopathy secondary to vasculitis, since the patient exhibited lesions and clinical history compatible with this condition. Accordingly, the patient was given a treatment with oclacitinib at a dose of 0.6 mg/kg every 12 h for 60 days, and at a dose of 0.6 mg/kg every 24 h thereafter. This treatment resulted in significant improvement of the lesions, with only scars remaining. Complete blood count and biochemical tests performed after two months of treatment returned values within the normal ranges. Side effects from the medication used were not observed. Six months after commencement of oclacitinib administration, the patient remained stable and exhibited no new lesions. 

Discussion: Cutaneous vasculopathies are not biased by breed, and are secondary to deposition of immune complexes that develop owing to factors such as presence of pathogenic agents, immune-mediated diseases, exposure to viral particles present in the rabies vaccine, and alimentary hypersensitivities, among others. This condition is divided into five distinct categories, among which juvenile-onset ischemic dermatopathy is included. A specific treatment for this condition is not established, as it has peculiar characteristics. However, reported studies have demonstrated good results with the use of oclacitinib maleate. This drug is an inhibitor of Janus kinase, an enzyme involved in hypersensitivity reactions and pruritus in dogs. Published studies have reported that oclacitinib is effective for the control of the inflammatory processes that occur in this type of cutaneous vasculopathy, which explains the therapeutic success in the case described here. 


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How to Cite

Cousandier, G., Scholten, A. D., Scotton, G., & Stefanello, C. (2021). Juvenile-Onset Ischemic Dermatopathy in a Dog. Acta Scientiae Veterinariae, 49. https://doi.org/10.22456/1679-9216.105583