Role of advanced glycation end products related to the onset of diabetic kidney disease complications

Maria Luiza Almeida de Paula, Ana Marina Rodrigues Villela, Mauricio Massucati Negri, Salim Kanaan, Luciene de Carvalho Cardoso Weide

Abstract


Advanced glycation end products are known to play an important role in the diabetes complications, such as diabetic nephropathy. Most known pathways of diabetic complications involve oxidative stress, that have pivotal role in cell dysfunction onset and progression of angiopathies. This review will explore how AGEs cause endothelial dysfunction in diabetes and what current biochemical mechanisms have been proposed as an explanation for the development of diabetic nephropathy.

Keywords: Type 2 diabetes mellitus; advanced glycation end products; endothelial dysfunction; hyperglycemia; oxidative stress; vascular complication; diabetic nephropathy 


Keywords


Type 2 diabetes mellitus; advanced glycation end products; endothelial dysfunction; hyperglycemia; oxidative stress; vascular complication; diabetic nephropathy

Full Text:

PDF


Copyright (c) 2017 Clinical & Biomedical Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN: 2357-9730 

http://seer.ufrgs.br/hcpa/

   

  

 

Apoio Financeiro:

  

 

Licença Creative Commons
The Clinical & Biomedical Research is licenced under Creative Commons Atribuição 4.0 Internacional.